Cefcapene pivoxil hydrochloride hydrate (oral administration; 100mg/kg; 4 days) is effective against invasive BLNAR strains in mice lung, it stimates peak antibiotic concentrations of 1 to 2 μg/ml in the blood of mice from 30 to 120 min after intragastric administration. Animal Model: Four-week-old female C57BL/6J mice with bacterial suspension in BSG (1×10 9 CFU) Dosage: 100 mg/kg Administration: Oral administration; 100mg/kg; 4 days Result: Was against H. influenzae colonization in mouse lung.